Metabolomics

Blood lutein, zeaxanthin, and melatonin analysis.

According to the AREDS2 (Age-Related Eye Disease Study 2) conducted by NEI of NIH, AREDS2 participants with lutein + zeaxanthin had an incremental increase in benefit for the AMD. Blood lutein and zeaxanthin concentrations have an effectiveness by the inverse relation with the AMD progression. Therefore, the analysis of blood lutein and/or zeaxanthin concentrations could be a new tool for estimating the AMD risk and monitoring the effectiveness of the antioxidants.

High Performance Liquid Chromatography (HPLC) is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. Using the HPLC technology, the concentration of lutein and/or zeaxanthin can be measured.

Lutein is isomeric with zeaxanthin, differing only in the placement of one double bond. Lutein and zeaxanthin can be interconverted in the body through an intermediate called meso-zeaxanthin.

Blood Lutein Analysis

Blood Zeaxanthin Analysis

Blood Melatonin Analysis

Lutein and zeaxanthin molecular structures

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